Archive for the ‘Engineering’ Category
Scientists plan $1.5bn laser strong enough ‘to tear the fabric of space
A laser powerful enough to tear apart the fabric of space could be built in Britain.
The major scientific project will follow in the footsteps of the Large Hadron Collider and will answer questions about the universe.
The laser will be capable of producing a beam of light so intense that it will be similar to the light the earth receives from the sun but focused on a speck smaller than a pin prick.
Extreme: A laser powerful enough to tear apart the fabric of space could be built in Britain.
Scientists say it will be so powerful they will be able to boil the very fabric of space and create a vacuum.
A vacuum fizzles with mysterious particles that come in and out of existence but the phenomenon happens so fast that no-one has ever actually been able to prove it.
It is hoped the Extreme Light Infrastructure Ultra-High Field Facility would allow scientists to prove the particles are real by pulling the vacuum fabric apart.
Scientists even believe it might help them to prove whether other dimensions actually exist.
This latest experiment will follow the footsteps of the Large Hadron Collider and be the next big scientific experiment.
Professor John Collier, a scientific leader for the ELI project and director of the Central Laser Facility at Rutherford Appleton Laboratory in Didcot, Oxfordshire, said the laser would be the most powerful on earth.
‘At this kind of intensity we start to get into unexplored territory as it is an area of physics that we have never been before,’ he told the Sunday Telegraph.
The ELI ultra-high field laser, which will be completed by the end of the decade, will cost £1bn and the UK is among a number of European countries in the running to house it.
The European Commission has already authorised plans for three more lasers which will become prototypes for the ultra-high field laser.
Scientists hope the laser will also allow them to see how particles inside an atom behave and it is hoped it might be able to explain the mystery of why the universe contains more matter than previously detected by revealing what dark matter really is.
HOW IT WILL WORK
- The ultra-high field laser will be made up of 10 beams – each more powerful than the prototype lasers.
- It will produce 200 petawatts of power – more than 100,000 times the power of the world’s combined electricity production but in less than a trillionth a second.
- The energy needed to power the laser will be stored up beforehand and then used to produce a beams several feet wide which will then be combined and eventually focused down onto a tiny spot.
- The intensity of the beam is so powerful and will produce such extreme conditions, that do not even exist in the center of the sun.
Powerful: The ultra-high field laser will be made up of 10 beams – each more powerful than the prototypes.
Via DailyMail
Genetically engineered mosquitoes pass lethal gene to offspring
- Scientists carry out ‘positive’ trial on Cayman Islands
- New breed of insect could be used to tackle malaria and dengue fever
- But critics say it could lead to public health problems
Breakthrough or danger? A UK-based research team has found a way of genetically modifying the Aedes aegypti mosquito so they pass on a deadly gene to their offspring
Serious concerns have been raised over the release of a new breed of disease-fighting mosquito which has been genetically engineered to kill their own offspring.
There are hopes the project could be used to control agricultural pests and tackle deadly insect-borne illnesses such as dengue fever and malaria.
But the research has raised concerns about the possible side-effects on public health and the environment because, once released, the mosquitos cannot be recalled.
A UK-based scientific team revealed there had been positive signs from the first release into the environment of the mosquitoes, which are engineered to pass a lethal gene onto their offspring, killing them before adulthood.
The study team – which includes experts from Imperial College London and the Liverpool School of Tropical Medicine – released batches of modified mosquitoes in an area of the Cayman Islands where the dengue virus-carrying Aedes aegypti mosquito is common.
The study, published in Nature Biotechnology journal, looked at how successfully the lab-reared, genetically modified insects could mate.
About 19,000 mosquitoes engineered in a lab were released over four weeks in 2009 in a 25-acre area on Grand Cayman island.
Based on data from traps, the genetically engineered males accounted for 16per cent of the overall male population in the test zone, and the lethal gene was found in almost 10 percent of larvae.
Those figures suggest the genetically engineered males were about half as successful in mating as wild ones, a rate sufficient to suppress the population.
Disease fighter? The new breed of mosquitoes could be used to tackle killer illnesses like dengue fever and malaria which affect the world’s poorest populations
Luke Alphey, chief scientific officer at Oxitec, the firm which devised the technique, told the BBC: ‘We were really surprised how well they did.
‘For this method, you just need to get a reasonable proportion of the females to mate with GM males – you’ll never get the males as competitive as the wild ones, but they don’t have to be, they just have to be reasonably good.’
HOW MOSQUITOES KILL THEIR OWN CHILDREN
- The genetic approach used to create the mosquitoes is a system known as tetracycline-controlled transcriptional activation (tTA).
- The technique is an extension of one successfully used for decades to control or eradicate pests which involves sterilising millions of insects with radiation.
- But the process has not worked with mosquitoes, partly because the radiation also injures them, making it difficult for them to compete with healthy counterparts for mates.
- So Oxitec has now created the Aedes aegypti mosquitoes with a gene that will kill them unless they are given the common antibiotic tetracycline.
- With tetracycline provided in the lab, the mosquitoes can be bred for generations and multiplied.
- Males are then released into the wild, where tetracycline is not available.
- They live long enough to mate but their progeny will die before adulthood.
Authorities in the Florida Keys hope to carry out an open-air test on the modified insects as early as December after experiencing the region’s first cases of dengue fever in decades.
Dr Alphey said the technique was safe because only males were released as it was only the females that bite people and spread the disease.
But critics say the process is by no means foolproof.
Alfred Handler, a geneticist at the Agriculture Department in Gainesville, Florida, said the mosquitoes can evolve resistance to the lethal gene while being bred for generations in a lab.
Todd Shelly, an entomologist for the Agriculture Department in Hawaii, also said in a commentary published on Sunday by Nature Biotechnology that 3.5per cent of the insects in a lab test survived to adulthood despite presumably carrying the lethal gene.
Also, the sorting of male and female mosquitoes, which is done by hand, can result in up to 0.5per cent of the released insects being female, the commentary said.
If millions of mosquitoes were released, even that small percentage of females could lead to a temporary increase in disease spread, it was reported by the New York Times.
Oxitec and a molecular biologist, Anthony A. James of the University of California, Irvine, say they have developed a solution — a genetic modification that makes female mosquitoes, but not males, unable to fly.
The grounded females cannot mate or bite people, and separating males from females before release would be easier.
The World Health Organisation expects to release guidance on how GM insects should be deployed in developing countries by the end of the year.
Via DailyMail
Pilotless Boeing aircraft raises prospect manned dogfights 65000ft
The maiden flight of a revolutionary drone aircraft that can stay in the air for four days at 65,000 feet is just days away.
The Phantom Eye, made by Boeing’s secretive Phantom Works division, is powered by hydrogen and is designed to carry out surveillance and reconnaissance missions while remaining at high altitude. It will produce only water as a by-product.
Its inaugural flight will take place at Edwards Air Force Base in California and is expected to last between four and eight hours.
Phantom Eye: The technology behind it means pilotless dog-fights have come a step closer
Boeing also is developing a larger unmanned plane that will stay aloft for more than 10 days and ‘Phantom Ray,’ a fighter-sized UAV that will be a test bed for more advanced technologies, which made its inaugural flight in April.
The drone technologies being developed by Phantom Works mean the day when dog fights take place between unmanned aircraft is getting much closer.
‘Phantom Eye is the first of its kind and could open up a whole new market in collecting data and communications,’ Darryl Davis, president of Boeing Phantom Works, said.
‘It is a perfect example of turning an idea into a reality. It defines our rapid prototyping efforts and will demonstrate the art-of-the-possible when it comes to persistent intelligence, surveillance and reconnaissance.
‘The capabilities inherent in Phantom Eye’s design will offer game-changing opportunities for our military, civil and commercial customers.’
An artist’s impression of the high-altitude spy plane.
‘It’s exciting to be part of such a unique aircraft,’ said Drew Mallow, Phantom Eye program manager for Boeing.
‘The hydrogen propulsion system will be the key to Phantom Eye’s success. It is very efficient and offers great fuel economy, and its only byproduct is water, so it’s also a “green” aircraft.’
Phantom Eye is powered by two 2.3-litre, four-cylinder engines that provide 150 horsepower each. It has a 150-foot wingspan, will cruise at approximately 150 knots and can carry up to a 450-pound payload.
Via DailyMail
The floating city that could become the future of life at sea
- Yacht island comes with 11 accommodation decks and four helipads
- Designed to move on four platforms, each with thrusters to keep it stable
It looks like something straight out of a James Bond film – but a British firm believes this floating building could be the future of life at sea.
With 11 accommodation decks, a 360-degree observation area, four helipads, its own dock, several swimming pools and as much space as a cruise liner, it’s not so much a boat as a city.
Although it certainly does not fit the mould of a yacht, the design, called ‘Project Utopia’, was unveiled to stunned onlookers at the glitzy Monaco Yacht Show.
Fantasy island: As this artist’s impression shows, Project Utopia is more like a floating city than a boat.
Designer BMT Nigel Gee, of Southampton, Hants, has not yet put a figure on how much the floating island might cost to create or what sort of customer would want to buy it.
The boat is designed to float on four platforms, each with thrusters to keep the whole yacht island stable, even in the extreme seas.
Able to move ‘at slow speeds’, it stretches 65m above the sea’s surface, providing visitors to the 13th floor observation deck with panoramic views.
Just below, the top deck of the main accommodation and service spaces – which could house shops, bars and restaurants – would be covered by a retractable canopy.
Yacht Design Director James Roy believes it challenges preconceptions of traditional naval architecture.
All at sea: Project Utopia is designed to float on four platforms, each with thrusters to keep the whole island stable.
He said: ‘Visions of the future are often constrained by familiarity with the present or a reflection on the past.
‘Much is made in today’s design community of starting with a blank sheet of paper yet many, if not all yacht concepts revert back to the traditional form.
‘Because of the perception that a yacht should be a form of transport it becomes an immediate design constraint.
‘Utopia is not an object to travel in, it is a place to be, an island established for anyone who has the vision to create such a place.’
A design for life: A graphic showing the schematics of the yacht island, which comes with with 11 accommodation decks, a 360-degree observation area, four helipads and several swimming pools.
In the middle, a large column plunges down into the water, acting as a mooring system and housing a wet dock providing access from the sea.
James said the design, which has been created in partnership with Yacht Island Design, represents how the firm, which works on yachts, commercial and naval craft, uses state-of-the-art technology to bring innovation to the industry.
From fiction to reality: Project Utopia looks remarkably like Stromberg’s lair in Bond film The Spy Who Loved Me.
He added: ‘Pioneering design ideas such as Utopia are exactly the types of projects that our team excel in.
‘Our forward-thinking approach and unrivalled state-of-the-art engineering experience allows us to work closely with designers, stylists and shipyards, and bring these ideas to life.’
Via DailyMail
Declassified US Spy Satellites Reveal Rare Look at Secret Cold War Space Program
Twenty-five years after their top-secret, Cold War-era missions ended, two clandestine American satellite programs were declassified Saturday (Sept. 17) with the unveiling of three of the United States’ most closely guarded assets: the KH-7 GAMBIT, the KH-8 GAMBIT 3 and the KH-9 HEXAGON spy satellites.
The vintage National Reconnaissance Office satellites were displayed to the public Saturday in a one-day-only exhibit at the Smithsonian National Air and Space Museum’s Udvar-Hazy Center at Dulles Airport, Va. The three spacecraft were the centerpiece of the NRO’s invitation-only, 50th Anniversary Gala celebration held at the center last evening.
Saturday’s spysat unveiling was attended by a number of jubilant NRO veterans who developed and refined the classified spacecraft and its components for decades in secret, finally able to show their wives and families what they actually did ‘at the office’ for so many years. Both of the newly declassified satellite systems, GAMBIT and HEXAGON, followed the U.S. military’s frontrunner spy satellite system CORONA, which was declassified in 1995.
This National Reconnaissance Office released graphic depicts the huge HEXAGON spy satellite, a Cold War era surveillance craft that flew reconnaissance missions from 1971 to 1986. The bus-size satellites weighed 30,000 pounds and were 60 feet long.
Big spy satellites revealed
The KH-9 HEXAGON, often referred to by its popular nickname “Big Bird,” lived up to its legendary expectations. As large as a school bus, the KH-9 HEXAGON carried 60 miles of high resolution photographic film for space surveillance missions.
Military space historian Dwayne A. Day was exuberant after his first look at the KH-9 HEXAGON.
“This was some bad-ass technology,” Day told SPACE.com. “The Russians didn’t have anything like it.”
Day, co-editor of “Eye in the Sky: The Story of the CoronaSpy Satellites,” noted that “it took the Soviets on average five to 10 years to catch up during the Cold War, and in many cases they never really matched American capabilities.”
Phil Pressel, designer of the HEXAGON’s panoramic ‘optical bar’ imaging cameras, agreed with Day’s assessment.
“This is still the most complicated system we’ve ever put into orbit …Period.”
The HEXAGON’s twin optical bar panoramic mirror cameras rotated as the swept back and forth as the satellite flew over Earth, a process that intelligence officials referred to as “mowing the lawn.”
Phil Pressel, one of the developers of the KH-9 Hexagon’s panoramic camera system, proudly points out some of the spacecraft’s once highly-classified features, a life’s work that he had been unable to discuss publicly until the NRO’s Sept. 17, 2011 declassification of the massive spy satellite.
Each 6-inch wide frame of HEXAGON film capturing a wide swath of terrain covering 370 nautical miles — the distance from Cincinnati to Washington — on each pass over the former Soviet Union and China. The satellites had a resolution of about 2 to 3 feet (0.6 to nearly 1 meter), according to the NRO. [10 Ways the Government Watches You]
According to documents released by the NRO, each HEXAGON satellite mission lasted about 124 days, with the satellite launching four film return capsules that could send its photos back to Earth. An aircraft would catch the return capsule in mid-air by snagging its parachute following the canister’s re-entry.
In a fascinating footnote, the film bucket from the first KH-9 HEXAGON sank to the bottom of the Pacific Ocean in spring 1972 after Air Force recovery aircraft failed to snag the bucket’s parachute.
The film inside the protective bucket reported contained high resolution photographs of the Soviet Union’s submarine bases and missile silos. In a daredevil feat of clandestine ingenuity, the U.S. Navy’s Deep Submergence Vehicle Trieste II succeeded in grasping the bucket from a depth of 3 miles below the ocean.
Hubble vs. HEXAGON
Former International Space Station flight controller Rob Landis, now technical manager in the advanced projects office at NASA’s Wallops Flight Facility in Virginia, drove more than three hours to see the veil lifted from these legendary spacecraft.
Landis, who also worked on NASA’s Hubble Space Telescope program, noticed some distinct similarities between Hubble and the huge KH-9 HEXAGON reconnaissance satellite.
“I see a lot of Hubble heritage in this spacecraft, most notably in terms of spacecraft size,” Landis said. “Once the space shuttle design was settled upon, the design of Hubble — at the time it was called the Large Space Telescope — was set upon. I can imagine that there may have been a convergence or confluence of the designs. The Hubble’s primary mirror is 2.4 meters [7.9 feet] in diameter and the spacecraft is 14 feet in diameter. Both vehicles (KH-9 and Hubble) would fit into the shuttle’s cargo bay lengthwise, the KH-9 being longer than Hubble [60 feet]; both would also fit on a Titan-class launch vehicle.”
The ‘convergence or confluence’ theory was confirmed later in the day by a former spacecraft designer, who declined to be named but is familiar with both programs, who confided unequivocally: “The space shuttle’s payload bay was sized to accommodate the KH-9.”
The NRO launched 20 KH-9 HEXAGON satellites from California’s Vandenberg AFB from June 1971 to April 1986.
The HEXAGON’s final launch in April 1986 — just months after the space shuttle Challenger explosion — also met with disaster as the spy satellite’s Titan 34D booster erupted into a massive fireball just seconds after liftoff, crippling the NRO’s orbital reconnaissance capabilities for many months.
A side view of a KH-7 GAMBIT spy satellite on display at the Smithsonian National Air and Space Museum’s Udvar-Hazy Center at Dulles Airport, Va., on Sept. 17, 2011.
The spy satellite GAMBIT
Before the first HEXAGON spy satellite systems ever launched, the NRO’s GAMBIT series of reconnaissance craft flew several space missions aimed at providing surveillance over specific targets around the world.
The satellite program’s initial system, GAMBIT 1, first launched in 1963 carrying a KH-7 camera system that included a “77-inch focal length camera for providing specific information on scientific and technical capabilities that threatened the nation,” according to an NRO description. A second GAMBIT satellite system, which first launched aboard GAMBIT 3 in 1966, included a175-inch focal length camera.
The GAMBIT satellite program was active from July 1963 to April 1984. Both satellites were huge and launched out of Vandenberg Air Force Base.
The satellite series’ initial version was 15 feet (4.5 m) long and 5 feet (1.5 m) wide, and weighed about 1,154 pounds (523 kilograms). The GAMBIT 3 satellite was the same width but longer, stretching nearly 29 feet (9 m) long, not counting its Agena D rocket upper stage. It weighed about 4,130 pounds (1,873 kg).
Unlike the follow-up HEXAGON satellites, the GAMBIT series were designed for extremely short missions.
The GAMBIT 1 craft had an average mission life of about 6 1/2 days. A total of 38 missions were launched, though 10 of them were deemed failures, according to NRO documents.
The GAMBIT 3 series satellites had missions that averaged about 31 days. In all, 54 of the satellites were launched, with four failures recorded.
Like the CORONA and HEXAGON programs, the GAMBIT series of satellites returned their film to Earth in re-entry capsules that were then snatched up by recovery aircraft. GAMBIT 1 carried about 3,000 feet (914 meters) of film, while GAMBIT 3 was packed with 12,241 feet (3,731 meters) of film, NRO records show.
The behemoth HEXAGON was launched with 60 miles (320,000 feet) of film!
This image shows the flight profile for the NRO’s GAMBIT 3 spy satellite missions between 1966 and 1984. The program was declassified in Sept. 2011.
HEXAGON and GAMBIT 3 team up
During a media briefing, NRO officials confirmed to SPACE.com that the KH-8 GAMBIT 3 and KH-9 HEXAGON were later operated in tandem, teaming-up to photograph areas of military significance in both the former Soviet Union and China.
The KH-9 would image a wide swath of terrain, later scrutinized by imagery analysts on the ground for so-called ‘targets of opportunity.’ Once these potential targets were identified, a KH-8 would then be maneuvered to photograph the location in much higher resolution.
“During the era of these satellites — the GAMBIT and the HEXAGON — there was a Director of Central Intelligence committee known as the ‘Committee on Imagery Requirements and Exploitation’ that was responsible for that type of planning,” confirmed the NRO’s Robert McDonald, Director of the Center for the Study of National Reconnaissance.
NASA’s Rob Landis was both blunt and philosophical in his emotions over the declassification of the GAMBIT and HEXAGON programs.
“You have to give credit to leaders like President Eisenhower who had the vision to initiate reconnaissance spacecraft, beginning with the CORONA and Discoverer programs,” Landis said. “He was of the generation who wanted no more surprises, no more Pearl Harbors.”
“Frankly, I think that GAMBIT and HEXAGON helped prevent World War III.”
Via Space
‘Mind-reading device’ recreates what we see in our heads
Mind reading could become a reality after scientists unveiled a device which translates what we are seeing in our heads onto a screen.
By monitoring the brain activity of people while they watched Hollywood movie trailers, researchers were able to recreate a moving picture similar to the real footage being played.
While the technology is not yet capable of reading our thoughts, it could eventually lead to ways of translating our dreams and memories onto screen.
If it is refined enough the method could even be used to explore the minds of stroke patients, experts said.
Researchers from the University of California, Berkeley, used MRI scanners to monitor the blood flow in people’s brains as they watched films including Madagascar 2, Pink Panther 2 and Star Trek unfold on a screen.
After analysing how the brain’s visual centre responded to on-screen movements, the scientists created a computer program which could accurately guess what the person was looking at.
When the researchers watched a second set of clips, this time Hollywood film trailers, the programme was able to produce an approximate version of what they were watching.
It did this by scanning a library of random YouTube videos, pulling out the most similar clips to what it guessed the person was watching, and blending them together.
Because the program’s video library contains just 18 million seconds of footage – a relatively small amount – it is highly unlikely that any clip will be very similar to the real footage.
To combat this problem, the program averages together the 100 shots from the video library that it thinks are the best match.
The result is a blurry but continuous video in which the movements of the shapes on screen reflect the action in the genuine Hollywood trailer.
Prof Jack Gallant, one of the study’s authors, said: “We’re trying to reconstruct the movie that was seen by searching through a large library of completely different, random movies.
“This is a major leap toward reconstructing internal imagery. We are opening a window into the movies in our minds.”
The averaging process makes the resulting video blurry, but the researchers said boosting the size of the programme’s video library could improve the quality of the reconstruction.
The study, published in the Current Biology journal, is believed to be the first experiment to successfully interpret brain signals as they respond to moving images.
The current technology can only process film clips that people have already viewed, but the breakthrough could lead to programmes which can reproduce dreams and memories because our natural visual experience is similar to watching a film.
We are still decades from a machine which can read people’s thoughts and intentions, but the technology could eventually be used to read the minds of stroke and coma patients, and to allow cerebral palsy or paralysis sufferers to guide computers with their minds, researchers said.
Watch video here
Via Telegraph
Gene that lights up under green light could help find cure for HIV
Glowing kittens with resistance to disease have been created by scientists searching for a cure for Aids.
The domestic cats had their DNA modified with a gene that fights off an HIV-like virus and a second one – from a fluorescent jellyfish – that makes their bodies shine green under ultraviolet light.
The purpose of the study was to show how a natural protein that prevents macaque monkeys developing Aids can do the same in cats.
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Way to glow: The eerie looking feline that has been genetically modified with DNA from a fluorescent jellyfish protein
Hard to hide: The kitten’s fur, claws and whiskers emit an eerie green glow
The two genes are linked and the jellyfish gene is used to track the other one for the protein.
Shining a UV light on the cats produced an eerie green glow, confirming that the protein was being made in their tissues and that the technique had worked.
The genetically modified cats’ creators say the research will speed up the search for vaccines and treatments against HIV, the Aids virus that has claimed more than 30million lives around the world.
With HIV-like viruses also wreaking havoc among felines, from domestic moggies to big cats, the research could improve animal health.
In future, people could buy pets that are resistant to numerous diseases, removing the need for frequent and expensive trips to the vet for vaccination.
Novelty glow-in-the-dark breeds are also a possibility.
Test subject: Under normal lighting the cat’s ability to glow remains a secret
But critics say the technique takes a high toll on animal welfare and that scientists should be reducing the number of animals they experiment on.
The researchers, from the respected Mayo Clinic in the U.S., used harmless viruses to transfer genes into eggs removed from pet cats during routine spaying.
One gene makes a fluorescent protein, the other produces a protein that fights off feline immunodeficiency virus, or FIV, the cat version of HIV. The eggs were then fertilised through IVF and implanted in surrogate mothers.
Sharp thinking: The cat’s paws glow too. Scientists say that cats are the best subjects for this kind of research
Twenty-two attempts led to the birth of five kittens – three of which survived, the journal Nature Methods reports.
Two were healthy but one suffered medical problems, although the researchers do not believe they were linked to the genetic manipulation.
The anti-viral gene was also present and cells taken from the kittens were able to resist infection with FIV better than those from normal cats.
Two of the cats went on to have kittens of their own, all of which carried the new genes.
Immune System Trained to Kill Cancer
A year ago, when chemotherapy stopped working against his leukemia, William Ludwig signed up to be the first patient treated in a bold experiment at the University of Pennsylvania. Mr. Ludwig, then 65, a retired corrections officer from Bridgeton, N.J., felt his life draining away and thought he had nothing to lose.
Doctors removed a billion of his T-cells — a type of white blood cell that fights viruses andtumors — and gave them new genes that would program the cells to attack his cancer. Then the altered cells were dripped back into Mr. Ludwig’s veins.
At first, nothing happened. But after 10 days, hell broke loose in his hospital room. He began shaking with chills. His temperature shot up. Hisblood pressure shot down. He became so ill that doctors moved him into intensive care and warned that he might die. His family gathered at the hospital, fearing the worst.
A few weeks later, the fevers were gone. And so was the leukemia.
There was no trace of it anywhere — no leukemic cells in his blood or bone marrow, no more bulging lymph nodes on his CT scan. His doctors calculated that the treatment had killed off two pounds of cancer cells.
A year later, Mr. Ludwig is still in complete remission. Before, there were days when he could barely get out of bed; now, he plays golf and does yard work.
“I have my life back,” he said.
Mr. Ludwig’s doctors have not claimed that he is cured — it is too soon to tell — nor have they declared victory over leukemia on the basis of this experiment, which involved only three patients. The research, they say, has far to go; the treatment is still experimental, not available outside of studies.
But scientists say the treatment that helped Mr. Ludwig, described recently in The New England Journal of Medicine and Science Translational Medicine, may signify a turning point in the long struggle to develop effective gene therapies against cancer. And not just for leukemia patients: other cancers may also be vulnerable to this novel approach — which employs a disabled form of H.I.V.-1, the virus that causes AIDS, to carry cancer-fighting genes into the patients’ T-cells. In essence, the team is using gene therapy to accomplish something that researchers have hoped to do for decades: train a person’s own immune system to kill cancer cells.
Two other patients have undergone the experimental treatment. One had a partial remission: his disease lessened but did not go away completely. Another had a complete remission. All three had had advanced chronic lymphocytic leukemia and had run out of chemotherapy options. Usually, the only hope for a remission in such cases is a bone-marrow transplant, but these patients were not candidates for it.
Dr. Carl June, who led the research and directs translational medicine in the Abramson Cancer Center at the University of Pennsylvania, said that the results stunned even him and his colleagues, Dr. David L. Porter, Bruce Levine and Michael Kalos. They had hoped to see some benefit but had not dared dream of complete, prolonged remissions. Indeed, when Mr. Ludwig began running fevers, the doctors did not realize at first that it was a sign that his T-cells were engaged in a furious battle with his cancer.
Other experts in the field said the results were a major advance.
“It’s great work,” said Dr. Walter J. Urba of the Providence Cancer Center and Earle A. Chiles Research Institute in Portland, Ore. He called the patients’ recoveries remarkable, exciting and significant. “I feel very positive about this new technology. Conceptually, it’s very, very big.”
Dr. Urba said he thought the approach would ultimately be used against other types of cancer as well as leukemia and lymphoma. But he cautioned, “For patients today, we’re not there yet.” And he added the usual scientific caveat: To be considered valid, the results must be repeated in more patients, and by other research teams.
Dr. June called the techniques “a harvest of the information from the molecular biology revolution over the past two decades.”
Hitting a Genetic Jackpot
To make T-cells search out and destroy cancer, researchers must equip them to do several tasks: recognize the cancer, attack it, multiply, and live on inside the patient. A number of research groups have been trying to do this, but the T-cells they engineered could not accomplish all the tasks. As a result, the cells’ ability to fight tumors has generally been temporary.
The University of Pennsylvania team seems to have hit all the targets at once. Inside the patients, the T-cells modified by the researchers multiplied to 1,000 to 10,000 times the number infused, wiped out the cancer and then gradually diminished, leaving a population of “memory” cells that can quickly proliferate again if needed.
The researchers said they were not sure which parts of their strategy made it work — special cell-culturing techniques, the use of H.I.V.-1 to carry new genes into the T-cells, or the particular pieces of DNA that they selected to reprogram the T-cells.
The concept of doctoring T-cells genetically was first developed in the 1980s by Dr. Zelig Eshhar at the Weizmann Institute of Science in Rehovot, Israel. It involves adding gene sequences from different sources to enable the T-cells to produce what researchers call chimeric antigen receptors, or CARs — protein complexes that transform the cells into, in Dr. June’s words, “serial killers.”
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U.S. military drones that are so small they even look like insects
They look like children’s toys that are left discarded in wardrobes around the world.
But these innocent-looking devices are actually some of the most sophisticated drones on the planet.
The U.S. Air Force is developing the miniature spy craft with the goal of making them so small that they resemble birds and even insects.
Causing quite a buzz: Lead researcher Dr Gregory Parker holds a small, winged drone that resembles an insect. The U.S. military’s goal is to make the devices so small that they resemble birds and even insects.
Some even have moving wings that military chiefs hope will look so convincing that people won’t pay them any attention.
The Micro Air Vehicles (MAVs) are being developed at Wright-Patterson Air Force Base in Dayton, Ohio.
The base’s Air Force Research Laboratory mission is to develop MAVs that can find, track and target adversaries while operating in complex urban environments.
The engineers, led by Dr Gregory Parker, are using a variety of small helicopters and drones in the lab to develop the programs and software.
Testing takes place in a controlled indoor environment, during which data is gathered to analyse for further development.
An insect-sized drone. The U.S. Air Force Research Laboratory’s mission is to develop MAVs that can find, track and target adversaries while operating in complex urban environments.
You’ll believe a toy can spy: First Lieutenant Greg Sundbeck (left) and Dr Parker watch a test flight of a drone.
The trials are the latest research into tiny drones funded by the U.S. military.
The US Defense Advanced Research Projects Agency has spent years developing a whole host of cyborg critters, in the hopes of creating the ultimate ‘fly on the wall’.
Two years ago, researchers revealed that they had created cyborg beetles that can be guided wirelessly via a laptop.
Using implants, they worked out how to control a beetle’s take-off, flight and landing by stimulating the brain to work the wings.
First Lieutenant Sundbeck prepares a computer controlled drone for a test flight in the microaviary lab at Wright Patterson Air Force Base.
What on the outside appears cheap is actually camouflaged and sophisticated military equipment.
They controlled turns through stimulating the basilar muscles on one side or the other to make the wings on that side flap harder.
The embedded system uses nerve and muscle stimulators, a microbattery and a microcontroller with transceiver.
They were implanted in the beetles when they were at the pupal stage.
Three types of large beetles from Cameroon were used in the experiments at the University of California in Berkeley. The smallest was 2cm long, while the largest was 20cm.
First Lieutenant Zachary Goff operates the control console during a test flight at the Micro Air Vehicles lab.
Via DailyMail
Southern lights are sweeter in space
NASA
The greenish glow of an auroral display sweeps around Earth’s south polar region in this photo, captured from a vantage point on the International Space Station. The shuttle Atlantis and its robotic arm, as well as one of the station’s solar arrays, loom up in the foreground.
The pilot for NASA’s last space shuttle flight, Doug Hurley, says one of the highlights of Atlantis’ trip to the International Space Station was seeing an “incredible” display of southern lights — and after seeing these pictures, I’d have to agree with him.
This photo from the space station shows the greenish auroral glow sweeping around the south pole, following the edge of the atmosphere. Atlantis is in the foreground with its robotic arm extended into the center of the frame, and one of the station’s gold-colored solar arrays juts in the right edge. You can even see the stars hanging in the night sky.
Another picture provides a more detailed view of the shimmering lights, with Atlantis’ inspection boom poking through the frame.
NASA
Thursday night’s southern lights shimmer in a picture taken from the International Space Station, with Atlantis’ inspection boom angling through the picture.
The southern lights, like the northern lights, are sparked when electrically charged particles from the sun interact with Earth’s magnetic field. For more amazing views of Atlantis’ auroras, check out NASA’s photo gallery for the shuttle mission, as well as Space.com’s report about the pictures.
– Alan Boyle.
Teperdexrian 